Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.
Journal, issue, pages	J. Med. Chem., Vol. 59, Page 5095-5101, Year 2016
Publish date	Dec 21, 2015 (structure data deposition date)
Authors	Sutherell, C.L. / Tallant, C. / Monteiro, O.P. / Yapp, C. / Fuchs, J.E. / Fedorov, O. / Siejka, P. / Muller, S. / Knapp, S. / Brenton, J.D. ...Sutherell, C.L. / Tallant, C. / Monteiro, O.P. / Yapp, C. / Fuchs, J.E. / Fedorov, O. / Siejka, P. / Muller, S. / Knapp, S. / Brenton, J.D. / Brennan, P.E. / Ley, S.V.
External links	J. Med. Chem. / PubMed:27119626
Methods	X-ray diffraction
Resolution	1.47 - 2.3 Å
Structure data	PDB-5fh6: Crystal structure of the fifth bromodomain of human PB1 in complex with compound 10 Method: X-RAY DIFFRACTION / Resolution: 2.3 Å PDB-5fh7: Crystal structure of the fifth bromodomain of human PB1 in complex with compound 18 Method: X-RAY DIFFRACTION / Resolution: 1.47 Å PDB-5fh8: Crystal structure of the fifth bromodomain of human PB1 in complex with compound 28 Method: X-RAY DIFFRACTION / Resolution: 1.55 Å
Chemicals	ChemComp-5XM: (3~{R})-3-(piperidin-1-ylmethyl)-2,3-dihydro-1~{H}-pyrrolo[1,2-a]quinazolin-5-one ChemComp-HOH: WATER ChemComp-EDO: 1,2-ETHANEDIOL ChemComp-5XL: 6-chloranyl-3-[(dimethylamino)methyl]-4~{H}-pyrrolo[1,2-a]quinazolin-5-one ChemComp-5XK: 6-chloranyl-3-(2-ethylbutyl)-4~{H}-pyrrolo[1,2-a]quinazolin-5-one ChemComp-DMS: DIMETHYL SULFOXIDE / DMSO, precipitant*YM
Source	homo sapiens (human)
Keywords	TRANSCRIPTION / PBRM1 / BRG1-associated factor 180 / chromatin remodeling