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TitleTargeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.
Journal, issue, pagesStructure, Vol. 23, Page 2076-2086, Year 2015
Publish dateSep 14, 2015 (structure data deposition date)
AuthorsPobbati, A.V. / Han, X. / Hung, A.W. / Weiguang, S. / Huda, N. / Chen, G.Y. / Kang, C. / Chia, C.S. / Luo, X. / Hong, W. / Poulsen, A.
External linksStructure / PubMed:26592798
MethodsX-ray diffraction
Resolution2.183 - 2.305 Å
Structure data

PDB-5dq8:
Crystal structure of human transcription factor TEAD2 in complex with flufenamic acid
Method: X-RAY DIFFRACTION / Resolution: 2.305 Å

PDB-5dqe:
Crystal structure of human transcription factor TEAD2 in complex with bromo-fenamic acid
Method: X-RAY DIFFRACTION / Resolution: 2.183 Å

Chemicals

ChemComp-FLF:
2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID / antiinflammatory, inhibitor*YM

ChemComp-HOH:
WATER

ChemComp-5E4:
2-[(3-bromophenyl)amino]benzoic acid

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / flufenamates / cancer therapy / Hippo pathway

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