Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.
Journal, issue, pages	Nat Commun, Vol. 7, Page 10900-10900, Year 2016
Publish date	Jul 31, 2015 (structure data deposition date)
Authors	Huber, E.M. / Heinemeyer, W. / Li, X. / Arendt, C.S. / Hochstrasser, M. / Groll, M.
External links	Nat Commun / PubMed:26964885
Methods	X-ray diffraction
Resolution	2.3 - 2.9 Å
Structure data	PDB-5cz4: Yeast 20S proteasome at 2.3 A resolution Method: X-RAY DIFFRACTION / Resolution: 2.3 Å PDB-5cz5: Yeast 20S proteasome beta1-T1A mutant in complex with Carfilzomib Method: X-RAY DIFFRACTION / Resolution: 2.8 Å PDB-5cz6: Yeast 20S proteasome beta5-T1A mutant in complex with Syringolin A, propeptide expressed in trans Method: X-RAY DIFFRACTION / Resolution: 2.7 Å PDB-5cz7: Yeast 20S proteasome beta5-T1A beta5-K81R double mutant in complex with Bortezomib, propeptide expressed in cis Method: X-RAY DIFFRACTION / Resolution: 2.5 Å PDB-5cz8: Yeast 20S proteasome beta5-L(-49)S-K33A mutant in complex with Carfilzomib Method: X-RAY DIFFRACTION / Resolution: 2.8 Å PDB-5cz9: Yeast 20S proteasome beta5-D17N mutant in complex with Carfilzomib; Propeptide expressed in trans Method: X-RAY DIFFRACTION / Resolution: 2.9 Å PDB-5cza: Yeast 20S proteasome beta5-D166N mutant Method: X-RAY DIFFRACTION / Resolution: 2.5 Å PDB-5d0s: Yeast 20S proteasome beta5-D166N mutant in complex with Carfilzomib Method: X-RAY DIFFRACTION / Resolution: 2.5 Å PDB-5d0t: Yeast 20S proteasome beta5-D166N mutant in complex with MG132 Method: X-RAY DIFFRACTION / Resolution: 2.6 Å PDB-5d0v: Yeast 20S proteasome beta5-T1C mutant in complex with Carfilzomib Method: X-RAY DIFFRACTION / Resolution: 2.9 Å PDB-5d0w: Yeast 20S proteasome beta5-T1S mutant Method: X-RAY DIFFRACTION / Resolution: 2.8 Å PDB-5d0x: Yeast 20S proteasome beta5-T1S mutant in complex with Bortezomib Method: X-RAY DIFFRACTION / Resolution: 2.6 Å PDB-5d0z: Yeast 20S proteasome beta5-T1S mutant in complex with Carfilzomib Method: X-RAY DIFFRACTION / Resolution: 2.9 Å PDB-5fg7: Yeast 20S proteasome beta2-T1A mutant Method: X-RAY DIFFRACTION / Resolution: 2.7 Å PDB-5fg9: Yeast 20S proteasome beta2-T(-2)V mutant Method: X-RAY DIFFRACTION / Resolution: 2.6 Å PDB-5fga: Yeast 20S proteasome beta5-K33A mutant (propeptide expressed in trans) Method: X-RAY DIFFRACTION / Resolution: 2.7 Å PDB-5fgd: Yeast 20S proteasome beta5-H(-2)L-T1A double mutant in complex with Carfilzomib Method: X-RAY DIFFRACTION / Resolution: 2.8 Å PDB-5fge: Yeast 20S proteasome beta5-H(-2)T-T1A double mutant in complex with Carfilzomib Method: X-RAY DIFFRACTION / Resolution: 2.6 Å PDB-5fgf: Yeast 20S proteasome beta5-H(-2)A-T1A-K81R triple mutant in complex with Carfilzomib Method: X-RAY DIFFRACTION / Resolution: 2.6 Å PDB-5fgg: Yeast 20S proteasome beta5-L(-49S)_D17N double mutant in complex with Carfilzomib Method: X-RAY DIFFRACTION / Resolution: 2.7 Å PDB-5fgh: Yeast 20S proteasome beta5-K33A mutant (propeptide expressed in trans) in complex with MG132 Method: X-RAY DIFFRACTION / Resolution: 2.8 Å PDB-5fgi: Yeast 20S proteasome beta1-T1A beta2-T1A double mutant in complex with Carfilzomib Method: X-RAY DIFFRACTION / Resolution: 2.9 Å PDB-5fhs: Yeast 20S proteasome beta5-K33A mutant (propeptide expressed in trans) in complex with Carfilzomib Method: X-RAY DIFFRACTION / Resolution: 2.7 Å
Chemicals	ChemComp-MG: Unknown entry ChemComp-CL: Unknown entry / Chloride ChemComp-HOH: WATER / Water ChemComp-3BV: N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamide / medication, anticancer, inhibitorYM / Carfilzomib ChemComp-MES: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH bufferYM / MES (buffer) ChemComp-SRG: (2S)-2-[[(2S)-1-[[(5S,8S,9E)-2,7-dioxo-5-propan-2-yl-1,6-diazacyclododeca-3,9-dien-8-yl]amino]-3-methyl-1-oxo-butan-2-yl]carbamoylamino]-3-methyl-butanoic acid ChemComp-BO2: N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE / medication, anticancerYM / Bortezomib ChemComp-ALD*: N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide
Source	saccharomyces cerevisiae (strain atcc 204508 / s288c) (yeast) synthetic construct (others) saccharomyces cerevisiae s288c (yeast)
Keywords	HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE complex / Ubiquitin-Degradation System / Proteasome / NTN-Hydrolase / Thr-Protease / HYDROLASE-HYDROLASE INHIBITOR complex / Mutant / Inhibitor / Binding Analysis / HYDROLASE complex