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TitlePotent Inhibition of 3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic.
Journal, issue, pagesBiochemistry, Vol. 55, Page 6617-6629, Year 2016
Publish dateJul 15, 2015 (structure data deposition date)
AuthorsBalachandran, N. / Heimhalt, M. / Liuni, P. / To, F. / Wilson, D.J. / Junop, M.S. / Berti, P.J.
External linksBiochemistry / PubMed:27933795
MethodsX-ray diffraction
Resolution2.1181 Å
Structure data

PDB-5cks:
DAHP (3-deoxy-D-arabinoheptulosonate-7-phosphate) Synthase in complex with DAHP Oxime.
Method: X-RAY DIFFRACTION / Resolution: 2.1181 Å

Chemicals

ChemComp-GAL:
beta-D-galactopyranose

ChemComp-52L:
DAHP Oxime

ChemComp-HOH:
WATER

Source
  • escherichia coli (strain k12) (bacteria)
KeywordsTransferase/transferase inhibitor / DAHP synthase / Inhibitor / Complex / Transition state mimic / Transferase-transferase inhibitor complex

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