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Title | Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). |
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Journal, issue, pages | J. Med. Chem., Vol. 58, Page 8182-8199, Year 2015 |
Publish date | Jul 7, 2015 (structure data deposition date) |
![]() | Patel, S. / Harris, S.F. / Gibbons, P. / Deshmukh, G. / Gustafson, A. / Kellar, T. / Lin, H. / Liu, X. / Liu, Y. / Ma, C. ...Patel, S. / Harris, S.F. / Gibbons, P. / Deshmukh, G. / Gustafson, A. / Kellar, T. / Lin, H. / Liu, X. / Liu, Y. / Ma, C. / Scearce-Levie, K. / Ghosh, A.S. / Shin, Y.G. / Solanoy, H. / Wang, J. / Wang, B. / Yin, J. / Siu, M. / Lewcock, J.W. |
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Methods | X-ray diffraction |
Resolution | 1.7 - 2.28 Å |
Structure data | ![]() PDB-5cen: ![]() PDB-5ceo: ![]() PDB-5cep: ![]() PDB-5ceq: |
Chemicals | ![]() ChemComp-HOH: ![]() ChemComp-50D: ![]() ChemComp-50E: ![]() ChemComp-50F: |
Source |
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![]() | TRANSFERASE / kinase / TRANSFERASE/TRANSFERASE Inhibitor / TRANSFERASE-TRANSFERASE Inhibitor complex |