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TitleStructural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione
Journal, issue, pagesJ. Pharmacol. Sci., Vol. 129, Page 240-243, Year 2015
Publish dateSep 3, 2015 (structure data deposition date)
AuthorsYokoyama, T. / Takaki, S. / Chosa, K. / Sato, T. / Suico, M.A. / Teranishi, Y. / Shuto, T. / Mizuguchi, M. / Kai, H.
External linksJ. Pharmacol. Sci. / PubMed:26639444
MethodsX-ray diffraction
Resolution1.4 Å
Structure data

PDB-5ayt:
Crystal structure of transthyretin in complex with L6
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-L6Y:
2-oxidanyl-6-(phenylcarbonyl)benzo[de]isoquinoline-1,3-dione

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN/INHIBITOR / Amyloidogenic protein / Inhibitor / Stabilizer / Drug discovery / TRANSPORT PROTEIN-INHIBITOR complex

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