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Structure paper

Titlep62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
Journal, issue, pagesNat Commun, Vol. 7, Page 12030-12030, Year 2016
Publish dateMay 21, 2015 (structure data deposition date)
AuthorsSaito, T. / Ichimura, Y. / Taguchi, K. / Suzuki, T. / Mizushima, T. / Takagi, K. / Hirose, Y. / Nagahashi, M. / Iso, T. / Fukutomi, T. ...Saito, T. / Ichimura, Y. / Taguchi, K. / Suzuki, T. / Mizushima, T. / Takagi, K. / Hirose, Y. / Nagahashi, M. / Iso, T. / Fukutomi, T. / Ohishi, M. / Endo, K. / Uemura, T. / Nishito, Y. / Okuda, S. / Obata, M. / Kouno, T. / Imamura, R. / Tada, Y. / Obata, R. / Yasuda, D. / Takahashi, K. / Fujimura, T. / Pi, J. / Lee, M.S. / Ueno, T. / Ohe, T. / Mashino, T. / Wakai, T. / Kojima, H. / Okabe, T. / Nagano, T. / Motohashi, H. / Waguri, S. / Soga, T. / Yamamoto, M. / Tanaka, K. / Komatsu, M.
External linksNat Commun / PubMed:27345495
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-4zy3:
Crystal Structure of Keap1 in Complex with a small chemical compound, K67
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-FMT:
FORMIC ACID

ChemComp-K67:
N,N'-[2-(2-oxopropyl)naphthalene-1,4-diyl]bis(4-ethoxybenzenesulfonamide)

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsTRANSCRIPTION / Nrf2 / Keap1 / Stress sensor / Small molecule binding / Double glycine repeat / Kelch domain / p62

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