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Structure paper

TitleMain immunogenic region structure promotes binding of conformation-dependent myasthenia gravis autoantibodies, nicotinic acetylcholine receptor conformation maturation, and agonist sensitivity.
Journal, issue, pagesJ. Neurosci., Vol. 29, Page 13898-13908, Year 2009
Publish dateApr 29, 2015 (structure data deposition date)
AuthorsLuo, J. / Taylor, P. / Losen, M. / de Baets, M.H. / Shelton, G.D. / Lindstrom, J.
External linksJ. Neurosci. / PubMed:19890000
MethodsX-ray diffraction
Resolution2.2301 Å
Structure data

PDB-4zjs:
Crystal structure of a chimeric acetylcholine binding protein from Aplysia Californica (Ac-AChBP) containing the main immunogenic region (MIR) from the human alpha 1 subunit of the muscle nicotinic acetylcholine receptor in complex with anatoxin-A.
Method: X-RAY DIFFRACTION / Resolution: 2.2301 Å

Chemicals

ChemComp-4P0:
1-[(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl]ethanone

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • aplysia californica (California sea hare)
KeywordsIMMUNE SYSTEM / anatoxin-A / nicotinic / receptor / acetylcholine

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