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Title | Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics. |
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Journal, issue, pages | J. Med. Chem., Vol. 58, Page 4727-4737, Year 2015 |
Publish date | Mar 4, 2015 (structure data deposition date) |
![]() | Luz, J.G. / Antonysamy, S. / Kuklish, S.L. / Condon, B. / Lee, M.R. / Allison, D. / Yu, X.P. / Chandrasekhar, S. / Backer, R. / Zhang, A. ...Luz, J.G. / Antonysamy, S. / Kuklish, S.L. / Condon, B. / Lee, M.R. / Allison, D. / Yu, X.P. / Chandrasekhar, S. / Backer, R. / Zhang, A. / Russell, M. / Chang, S.S. / Harvey, A. / Sloan, A.V. / Fisher, M.J. |
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Methods | X-ray diffraction |
Resolution | 1.41 - 1.52 Å |
Structure data | ![]() PDB-4yk5: ![]() PDB-4yl0: ![]() PDB-4yl1: ![]() PDB-4yl3: |
Chemicals | ![]() ChemComp-4DV: ![]() ChemComp-PG0: ![]() ChemComp-GSH: ![]() ChemComp-JZR: ![]() ChemComp-BOG: ![]() ChemComp-PG4: ![]() ChemComp-HOH: ![]() ChemComp-4DZ: ![]() ChemComp-PEG: ![]() ChemComp-4U8: ![]() ChemComp-4U9: |
Source |
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![]() | ISOMERASE/ISOMERASE INHIBITOR / Inflammation / ISOMERASE-ISOMERASE INHIBITOR complex / Prostaglandin / Inhibitor |