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-Structure paper
Title | X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein. |
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Journal, issue, pages | J. Med. Chem., Vol. 58, Page 3156-3171, Year 2015 |
Publish date | Feb 25, 2015 (structure data deposition date) |
Authors | Molodtsov, V. / Fleming, P.R. / Eyermann, C.J. / Ferguson, A.D. / Foulk, M.A. / McKinney, D.C. / Masse, C.E. / Buurman, E.T. / Murakami, K.S. |
External links | J. Med. Chem. / PubMed:25798859 |
Methods | X-ray diffraction |
Resolution | 3.571 - 3.844 Å |
Structure data | PDB-4yfk: PDB-4yfn: PDB-4yfx: |
Chemicals | ChemComp-MG: ChemComp-ZN: ChemComp-4C6: ChemComp-4C2: ChemComp-4C4: |
Source |
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Keywords | transcription/transcription inhibitor / switch region / squaramide / transcription-inhibitor complex / transcription-transcription inhibitor complex |