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TitleParing Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region.
Journal, issue, pagesStructure, Vol. 24, Page 697-709, Year 2016
Publish dateFeb 18, 2015 (structure data deposition date)
AuthorsTolbert, W.D. / Gohain, N. / Veillette, M. / Chapleau, J.P. / Orlandi, C. / Visciano, M.L. / Ebadi, M. / DeVico, A.L. / Fouts, T.R. / Finzi, A. ...Tolbert, W.D. / Gohain, N. / Veillette, M. / Chapleau, J.P. / Orlandi, C. / Visciano, M.L. / Ebadi, M. / DeVico, A.L. / Fouts, T.R. / Finzi, A. / Lewis, G.K. / Pazgier, M.
External linksStructure / PubMed:27041594
MethodsX-ray diffraction
Resolution1.85 - 3.1 Å
Structure data

PDB-4ybl:
Crystal structure of the stabilized inner domain of clade A/E HIV-1 gp120 in complex with the ADCC mediating ANTI-HIV-1 antibody A32
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-4yc2:
Crystal structure of the stabilized inner domain of clade A/E HIV-1 gp120 from E. coli in complex with the antibody A32.
Method: X-RAY DIFFRACTION / Resolution: 3.02 Å

PDB-5fcu:
CRYSTAL STRUCTURE OF THE INNER DOMAIN OF CLADE A/E HIV-1 GP120 IN COMPLEX WITH THE ADCC-POTENT RHESUS MACAQUE ANTIBODY JR4
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

Source
  • human immunodeficiency virus 1
  • homo sapiens (human)
  • macaca mulatta (Rhesus monkey)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / ADCC / NON-NEUTRALIZING / ANTI-HIV-1 ENV ANTIBODY A32 / CD4I ANTIBODY / VIRAL GLYCOPROTEIN GP120 / HIV-1 ENV / VIRAL PROTEIN-IMMUNE SYSTEM complex / CLADE A/E 93TH057 / VIRAL PROTEIN / HIV-1 GP120

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