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Structure paper

Title2-(Isopropylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as selective phosphodiesterase 7 inhibitors with potent in vivo efficacy
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 25, Page 1910-1914, Year 2015
Publish dateFeb 9, 2015 (structure data deposition date)
AuthorsEndo, Y. / Kawai, K. / Asano, T. / Amano, S. / Asanuma, Y. / Sawada, K. / Onodera, Y. / Ueo, N. / Takahashi, N. / Sonoda, Y. ...Endo, Y. / Kawai, K. / Asano, T. / Amano, S. / Asanuma, Y. / Sawada, K. / Onodera, Y. / Ueo, N. / Takahashi, N. / Sonoda, Y. / Kamei, N. / Irie, T.
External linksBioorg. Med. Chem. Lett. / PubMed:25866242
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-4y2b:
Co-crystal structure of 3-ethyl-2-(isopropylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one bound to PDE7A
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-EPK:
3-ethyl-2-(propan-2-ylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / phosphodiesterase / PDE7A / cAMP / HYDROLASE-HYDROLASE INHIBITOR complex

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