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Structure paper

TitleStructural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.
Journal, issue, pagesScience, Vol. 347, Page 1113-1117, Year 2015
Publish dateJan 22, 2015 (structure data deposition date)
AuthorsBurg, J.S. / Ingram, J.R. / Venkatakrishnan, A.J. / Jude, K.M. / Dukkipati, A. / Feinberg, E.N. / Angelini, A. / Waghray, D. / Dror, R.O. / Ploegh, H.L. / Garcia, K.C.
External linksScience / PubMed:25745166
MethodsX-ray diffraction
Resolution2.886 - 3.801 Å
Structure data

PDB-4xt1:
Structure of a nanobody-bound viral GPCR bound to human chemokine CX3CL1
Method: X-RAY DIFFRACTION / Resolution: 2.886 Å

PDB-4xt3:
Structure of a viral GPCR bound to human chemokine CX3CL1
Method: X-RAY DIFFRACTION / Resolution: 3.801 Å

Chemicals

ChemComp-CLR:
CHOLESTEROL

ChemComp-OLC:
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate


ChemComp, No image

ChemComp-UNL:
Unknown ligand

ChemComp-SIN:
SUCCINIC ACID

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

Source
  • cytomegalovirus
  • homo sapiens (human)
  • vicugna pacos (alpaca)
KeywordsVIRAL PROTEIN/SIGNALLING PROTEIN / GPCR / chemokine / membrane protein / complex / VIRAL PROTEIN-SIGNALLING PROTEIN complex / VIRAL PROTEIN-CYTOKINE complex

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