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Structure paper

TitleIsoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2.
Journal, issue, pagesJ. Med. Chem., Vol. 58, Page 5930-5941, Year 2015
Publish dateJan 22, 2015 (structure data deposition date)
AuthorsScheuermann, T.H. / Stroud, D. / Sleet, C.E. / Bayeh, L. / Shokri, C. / Wang, H. / Caldwell, C.G. / Longgood, J. / MacMillan, J.B. / Bruick, R.K. ...Scheuermann, T.H. / Stroud, D. / Sleet, C.E. / Bayeh, L. / Shokri, C. / Wang, H. / Caldwell, C.G. / Longgood, J. / MacMillan, J.B. / Bruick, R.K. / Gardner, K.H. / Tambar, U.K.
External linksJ. Med. Chem. / PubMed:26226049
MethodsX-ray diffraction
Resolution1.698 Å
Structure data

PDB-4xt2:
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a tetrazole-containing antagonist
Method: X-RAY DIFFRACTION / Resolution: 1.698 Å

Chemicals

ChemComp-43L:
(5S,7R)-5,7-bis(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / transcription factor / Hypoxia Inducible Factor / inhibitor / cancer

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