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TitleMaturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 161, Page 470-485, Year 2015
Publish dateJan 14, 2015 (structure data deposition date)
AuthorsWu, X. / Zhang, Z. / Schramm, C.A. / Joyce, M.G. / Do Kwon, Y. / Zhou, T. / Sheng, Z. / Zhang, B. / O'Dell, S. / McKee, K. ...Wu, X. / Zhang, Z. / Schramm, C.A. / Joyce, M.G. / Do Kwon, Y. / Zhou, T. / Sheng, Z. / Zhang, B. / O'Dell, S. / McKee, K. / Georgiev, I.S. / Chuang, G.Y. / Longo, N.S. / Lynch, R.M. / Saunders, K.O. / Soto, C. / Srivatsan, S. / Yang, Y. / Bailer, R.T. / Louder, M.K. / Mullikin, J.C. / Connors, M. / Kwong, P.D. / Mascola, J.R. / Shapiro, L.
External linksCell(Cambridge,Mass. ) / PubMed:25865483
MethodsX-ray diffraction
Resolution1.69 - 3.39 Å
Structure data

PDB-4s1q:
Crystal structure of a VRC01-lineage antibody, 45-VRC01.H03+06.D-001739, in complex with clade A/E HIV-1 gp120 core
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4s1r:
Crystal structure of a VRC01-lineage antibody, 45-VRC01.H08.F-117225, in complex with clade A/E HIV-1 gp120 core
Method: X-RAY DIFFRACTION / Resolution: 3.214 Å

PDB-4s1s:
Crystal structure of a VRC01-lineage antibody, 45-VRC01.H5.F-185917, in complex with clade A/E HIV-1 gp120 core
Method: X-RAY DIFFRACTION / Resolution: 3.39 Å

PDB-4xmp:
Crystal structure of broadly and potently neutralizing antibody VRC08 in complex with HIV-1 clade A strain Q842.d12 gp120
Method: X-RAY DIFFRACTION / Resolution: 1.7831 Å

PDB-4xny:
Crystal structure of broadly and potently neutralizing antibody VRC08C in complex with HIV-1 clade A strain Q842.d12 gp120
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-4xnz:
Crystal structure of broadly and potently neutralizing antibody VRC06B in complex with HIV-1 clade A/E strain 93TH057 gp120
Method: X-RAY DIFFRACTION / Resolution: 3.389 Å

PDB-4xvs:
Crystal structure of HIV-1 donor 45 d45-01dG5 coreE gp120 with antibody 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 (VRC07_1995)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-4xvt:
Crystal structure of HIV-1 93TH057 coreE gp120 with antibody 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 (VRC07_1995)
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-BU3:
(R,R)-2,3-BUTANEDIOL

Source
  • human immunodeficiency virus 1
  • homo sapiens (human)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / HIV-1 / neutralizing antibodies / VRC01-lineage / antibody maturation / evolutionary rate / VIRAL PROTEIN-IMMUNE SYSTEM complex / VIRAL PROTEIN/IMMUNE SYSTEM/INHIBITOR / VIRAL PROTEIN-IMMUNE SYSTEM-INHIBITOR complex / IMMUNE SYSTEM / Antibody / HIV-1 antibodyomics neutralizing antibody germline binding

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