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Structure paper

TitleStructural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page 3812-3816, Year 2013
Publish dateJul 18, 2012 (structure data deposition date)
AuthorsJenner, L. / Starosta, A.L. / Terry, D.S. / Mikolajka, A. / Filonava, L. / Yusupov, M. / Blanchard, S.C. / Wilson, D.N. / Yusupova, G.
External linksProc. Natl. Acad. Sci. USA / PubMed:23431179
MethodsX-ray diffraction
Resolution3.1 - 3.2999 Å
Structure data

PDB-4v9a:
Crystal Structure of the 70S ribosome with tetracycline.
Method: X-RAY DIFFRACTION / Resolution: 3.2999 Å

PDB-4v9b:
Crystal Structure of the 70S ribosome with tigecycline.
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-TAC:
TETRACYCLINE / medication, antibiotic*YM

ChemComp-ZN:
Unknown entry

ChemComp-T1C:
TIGECYCLINE / medication, antibiotic*YM

Source
  • thermus thermophilus (bacteria)
  • synthetic dna (others)
  • synthetic construct (others)
KeywordsRIBOSOME/ANTIBIOTIC / RNA / ribosome / tRNA / translation / mRNA / RIBOSOME-ANTIBIOTIC complex

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