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Structure paper

TitleStructure of fungal fatty acid synthase and implications for iterative substrate shuttling.
Journal, issue, pagesScience, Vol. 316, Issue 5822, Page 254-261, Year 2007
Publish dateApr 13, 2007
AuthorsSimon Jenni / Marc Leibundgut / Daniel Boehringer / Christian Frick / Bohdan Mikolásek / Nenad Ban /
PubMed AbstractWe report crystal structures of the 2.6-megadalton alpha6beta6 heterododecameric fatty acid synthase from Thermomyces lanuginosus at 3.1 angstrom resolution. The alpha and beta polypeptide chains ...We report crystal structures of the 2.6-megadalton alpha6beta6 heterododecameric fatty acid synthase from Thermomyces lanuginosus at 3.1 angstrom resolution. The alpha and beta polypeptide chains form the six catalytic domains required for fatty acid synthesis and numerous expansion segments responsible for extensive intersubunit connections. Detailed views of all active sites provide insights into substrate specificities and catalytic mechanisms and reveal their unique characteristics, which are due to the integration into the multienzyme. The mode of acyl carrier protein attachment in the reaction chamber, together with the spatial distribution of active sites, suggests that iterative substrate shuttling is achieved by a relatively restricted circular motion of the carrier domain in the multifunctional enzyme.
External linksScience / PubMed:17431175
MethodsEM (single particle) / X-ray diffraction
Resolution3.1 - 15.0 Å
Structure data

EMDB-1338:
Structure of fungal fatty acid synthase and implications for iterative substrate shuttling.
Method: EM (single particle) / Resolution: 15.0 Å

PDB-4v58:
Crystal structure of fatty acid synthase from thermomyces lanuginosus at 3.1 angstrom resolution.
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-4v59:
Crystal structure of fatty acid synthase complexed with nadp+ from thermomyces lanuginosus at 3.1 angstrom resolution.
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

Source
  • thermomyces lanuginosus (fungus)
KeywordsTRANSFERASE / FUNGAL / DEHYDRATASE / ENOYL REDUCTASE / KETOACYL SYNTHASE / KETOACYL REDUCTASE / MALONYL/PALMITOYL TRANSFERASE / SUBSTRATE SHUTTLING / MULTIFUNCTIONAL ENZYME / ACYL CARRIER PROTEIN / FATTY ACID SYNTHESIS / ACETYL TRANSFERASE / FATTY ACID SYNTHASE

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