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-Structure paper
Title | The Discovery of I-Bet726 (Gsk1324726A), a Potent Tetrahydroquinoline Apoa1 Up-Regulator and Selective Bet Bromodomain Inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 8111-, Year 2014 |
Publish date | Aug 31, 2014 (structure data deposition date) |
Authors | Gosmini, R. / Nguyen, V.L. / Toum, J. / Simon, C. / Brusq, J.M. / Krysa, G. / Mirguet, O. / Riou-Eymard, A.M. / Boursier, E.V. / Trottet, L. ...Gosmini, R. / Nguyen, V.L. / Toum, J. / Simon, C. / Brusq, J.M. / Krysa, G. / Mirguet, O. / Riou-Eymard, A.M. / Boursier, E.V. / Trottet, L. / Bamborough, P. / Clark, H. / Chung, C.W. / Cutler, L. / Demont, E.H. / Kaur, R. / Lewis, A.J. / Schilling, M.B. / Soden, P.E. / Taylor, S. / Walker, A.L. / Walker, M.D. / Prinjha, R.K. / Nicodeme, E. |
External links | J. Med. Chem. / PubMed:25249180 |
Methods | X-ray diffraction |
Resolution | 1.6 - 2.5 Å |
Structure data | PDB-4uyf: PDB-4uyg: PDB-4uyh: |
Chemicals | ChemComp-EDO: ChemComp-73B: ChemComp-SO4: ChemComp-HOH: ChemComp-9S3: ChemComp-DMS: |
Source |
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Keywords | TRANSCRIPTION / INHIBITOR / HISTONE / EPIGENETIC READER / BET / BRD2 / BROMODOMAIN |