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-Structure paper
Title | Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 24, Page 4714-4723, Year 2014 |
Publish date | Jul 31, 2014 (structure data deposition date) |
![]() | Robarge, K.D. / Lee, W. / Eigenbrot, C. / Ultsch, M. / Wiesmann, C. / Heald, R. / Price, S. / Hewitt, J. / Jackson, P. / Savy, P. ...Robarge, K.D. / Lee, W. / Eigenbrot, C. / Ultsch, M. / Wiesmann, C. / Heald, R. / Price, S. / Hewitt, J. / Jackson, P. / Savy, P. / Burton, B. / Choo, E.F. / Pang, J. / Boggs, J. / Yang, A. / Yang, X. / Baumgardner, M. |
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Methods | X-ray diffraction |
Resolution | 2.701 - 2.805 Å |
Structure data | ![]() PDB-4u7z: ![]() PDB-4u80: ![]() PDB-4u81: |
Chemicals | ![]() ChemComp-MG: ![]() ChemComp-3EW: ![]() ChemComp-ANP: ![]() ChemComp-HOH: ![]() ChemComp-3EX: ![]() ChemComp-3EY: |
Source |
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![]() | TRANSFERASE/TRANSFERASE Inhibitor / ![]() ![]() ![]() |