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-Structure paper
Title | Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 24, Page 4546-4552, Year 2014 |
Publish date | Jul 23, 2014 (structure data deposition date) |
![]() | Wang, L. / Stanley, M. / Boggs, J.W. / Crawford, T.D. / Bravo, B.J. / Giannetti, A.M. / Harris, S.F. / Magnuson, S.R. / Nonomiya, J. / Schmidt, S. ...Wang, L. / Stanley, M. / Boggs, J.W. / Crawford, T.D. / Bravo, B.J. / Giannetti, A.M. / Harris, S.F. / Magnuson, S.R. / Nonomiya, J. / Schmidt, S. / Wu, P. / Ye, W. / Gould, S.E. / Murray, L.J. / Ndubaku, C.O. / Chen, H. |
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Methods | X-ray diffraction |
Resolution | 2.18 - 2.58 Å |
Structure data | ![]() PDB-4u43: ![]() PDB-4u44: ![]() PDB-4u45: |
Chemicals | ![]() ChemComp-3D8: ![]() ChemComp-HOH: ![]() ChemComp-MES: ![]() ChemComp-NA: ![]() ChemComp-3D9: ![]() ChemComp-MG: ![]() ChemComp-3DC: |
Source |
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![]() | Transferase/Transferase inhibitor / kinase / Transferase-Transferase inhibitor complex |