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TitleIdentification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells.
Journal, issue, pagesCell Metab, Vol. 21, Page 286-297, Year 2015
Publish dateJan 7, 2015 (structure data deposition date)
AuthorsSantori, F.R. / Huang, P. / van de Pavert, S.A. / Douglass, E.F. / Leaver, D.J. / Haubrich, B.A. / Keber, R. / Lorbek, G. / Konijn, T. / Rosales, B.N. ...Santori, F.R. / Huang, P. / van de Pavert, S.A. / Douglass, E.F. / Leaver, D.J. / Haubrich, B.A. / Keber, R. / Lorbek, G. / Konijn, T. / Rosales, B.N. / Rozman, D. / Horvat, S. / Rahier, A. / Mebius, R.E. / Rastinejad, F. / Nes, W.D. / Littman, D.R.
External linksCell Metab / PubMed:25651181
MethodsX-ray diffraction
Resolution1.897 - 3.542 Å
Structure data

PDB-4s14:
Crystal structure of the orphan nuclear receptor RORgamma ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8)
Method: X-RAY DIFFRACTION / Resolution: 3.542 Å

PDB-4s15:
Crystal structure of the orphan nuclear receptor RORalpha ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8)
Method: X-RAY DIFFRACTION / Resolution: 1.897 Å

Chemicals

ChemComp-4D8:
(3beta,4alpha,5beta,14beta)-3-hydroxy-4-methylcholesta-8,24-diene-4-carboxylic acid

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / transcription factor

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