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TitleDesign of a potent antibiotic peptide based on the active region of human defensin 5.
Journal, issue, pagesJ. Med. Chem., Vol. 58, Page 3083-3093, Year 2015
Publish dateSep 13, 2014 (structure data deposition date)
AuthorsWang, C. / Shen, M. / Gohain, N. / Tolbert, W.D. / Chen, F. / Zhang, N. / Yang, K. / Wang, A. / Su, Y. / Cheng, T. ...Wang, C. / Shen, M. / Gohain, N. / Tolbert, W.D. / Chen, F. / Zhang, N. / Yang, K. / Wang, A. / Su, Y. / Cheng, T. / Zhao, J. / Pazgier, M. / Wang, J.
External linksJ. Med. Chem. / PubMed:25782105
MethodsX-ray diffraction
Resolution1.1 - 1.5 Å
Structure data

PDB-4rbw:
Crystal structure of human alpha-defensin 5, HD5 (Thr7Arg Glu21Arg mutant)
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-4rbx:
Crystal structure of human alpha-defensin 5, HD5 (Glu21Arg mutant)
Method: X-RAY DIFFRACTION / Resolution: 1.1 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsANTIMICROBIAL PROTEIN / MUTANT T7R E21R-HD5 / BETA-SHEET / ANTIMICROBIAL PEPTIDE / PANETH CELLS DEFENSIN / HUMAN ALPHA-DEFENSIN / MUTANT E21R-HD5

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