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TitleIdentification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 25, Page 1597-1602, Year 2015
Publish dateAug 7, 2014 (structure data deposition date)
AuthorsDorsch, D. / Schadt, O. / Stieber, F. / Meyring, M. / Gradler, U. / Bladt, F. / Friese-Hamim, M. / Knuhl, C. / Pehl, U. / Blaukat, A.
External linksBioorg. Med. Chem. Lett. / PubMed:25736998
MethodsX-ray diffraction
Resolution1.2 - 2 Å
Structure data

PDB-4r1v:
Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors
Method: X-RAY DIFFRACTION / Resolution: 1.2 Å

PDB-4r1y:
Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-3E8:
3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile

ChemComp-GBL:
GAMMA-BUTYROLACTONE

ChemComp-HOH:
WATER

ChemComp-3EH:
3-(diethylamino)propyl (3-{[5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3(6H)-yl]methyl}phenyl)carbamate

ChemComp-7PE:
2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / PROTEIN KINASE / Transferase / TRANSFERASE-TRANSFERASE INHIBITOR complex / Transferase inhibitor

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