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Structure paper

TitleCrystal structure of an Anticalin with specific blocking activity towards human vascular endothelial growth factor (VEGF) reveals plasticity of the lipocalin fold
Journal, issue, pagesTo be Published
Publish dateMay 4, 2014 (structure data deposition date)
AuthorsGiese, T. / Skerra, A.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-4qaf:
Crystal structure of an engineered lipocalin (Anticalin) in complex with VEGF(8-109)
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-OMA:
10-{(1R,2R)-2-[(2E)-hex-2-en-1-yl]cyclopropyl}decanoic acid

ChemComp-SO4:
SULFATE ION

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN/SIGNALING PROTEIN / beta-barrel / binding protein / engineered lipocalin / TRANSPORT PROTEIN-SIGNALING PROTEIN complex

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