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Structure paper

TitleHuman framework adaptation of a mouse anti-human IL-13 antibody.
Journal, issue, pagesJ. Mol. Biol., Vol. 398, Page 214-231, Year 2010
Publish dateDec 22, 2009 (structure data deposition date)
AuthorsFransson, J. / Teplyakov, A. / Raghunathan, G. / Chi, E. / Cordier, W. / Dinh, T. / Feng, Y. / Giles-Komar, J. / Gilliland, G. / Lollo, B. ...Fransson, J. / Teplyakov, A. / Raghunathan, G. / Chi, E. / Cordier, W. / Dinh, T. / Feng, Y. / Giles-Komar, J. / Gilliland, G. / Lollo, B. / Malia, T.J. / Nishioka, W. / Obmolova, G. / Zhao, S. / Zhao, Y. / Swanson, R.V. / Almagro, J.C.
External linksJ. Mol. Biol. / PubMed:20226193
MethodsX-ray diffraction
Resolution1.9 - 2.8 Å
Structure data

PDB-3l5w:
Crystal structure of the complex between IL-13 and C836 FAB
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-3l5x:
Crystal structure of the complex between IL-13 and H2L6 FAB
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-3l7f:
Structure of IL-13 antibody H2L6, A humanized variant OF C836
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-4ps4:
Crystal structure of the complex between IL-13 and M1295 FAB
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-SO4:
SULFATE ION

ChemComp-CA:
Unknown entry

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / immunoglobulin fold / alpha-helical bundle / Cytokine / Disulfide bond / Glycoprotein / Polymorphism / Secreted / MONOCLONAL ANTIBODY

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