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TitleDiscovery of 2-(Cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one Derivatives as a New Series of Potent Phosphodiesterase 7 Inhibitors.
Journal, issue, pagesJ. Med. Chem., Vol. 57, Page 9844-9854, Year 2014
Publish dateMay 20, 2014 (structure data deposition date)
AuthorsKawai, K. / Endo, Y. / Asano, T. / Amano, S. / Sawada, K. / Ueo, N. / Takahashi, N. / Sonoda, Y. / Nagai, M. / Kamei, N. / Nagata, N.
External linksJ. Med. Chem. / PubMed:25383422
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-4pm0:
PDE7A catalytic domain in complex with 2-(Cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivative
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-32V:
2-(cyclopentylamino)-3-ethyl-7-ethynylthieno[3,2-d]pyrimidin-4(3H)-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / phosphodiesterase / PDE7

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