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-Structure paper
Title | Discovery and structure-based optimization of adenain inhibitors. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 5, Page 937-941, Year 2014 |
Publish date | May 8, 2014 (structure data deposition date) |
Authors | Mac Sweeney, A. / Grosche, P. / Ellis, D. / Combrink, K. / Erbel, P. / Hughes, N. / Sirockin, F. / Melkko, S. / Bernardi, A. / Ramage, P. ...Mac Sweeney, A. / Grosche, P. / Ellis, D. / Combrink, K. / Erbel, P. / Hughes, N. / Sirockin, F. / Melkko, S. / Bernardi, A. / Ramage, P. / Jarousse, N. / Altmann, E. |
External links | Acs Med. Chem. Lett. / PubMed:25147618 |
Methods | X-ray diffraction |
Resolution | 1.59 - 2.1 Å |
Structure data | PDB-4pid: PDB-4pie: PDB-4piq: PDB-4pis: |
Chemicals | ChemComp-ACT: ChemComp-2UQ: ChemComp-HOH: ChemComp-3FO: ChemComp-SO4: ChemComp-ZN: ChemComp-3FS: ChemComp-3FU: |
Source |
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Keywords | Hydrolase/Hydrolase Inhibitor / Adenain / cysteine protease / adenovirus / pVIc cofactor / virus maturation / Hydrolase-Hydrolase Inhibitor complex / cofactor / pVIc / inhibitor / nitrile inhibitor |