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TitleSynthesis, broad spectrum antibacterial activity, and X-ray co-crystal structure of the decoding bacterial ribosomal A-site with 4'-deoxy-4'-fluoro neomycin analogs
Journal, issue, pagesChem Sci, Vol. 5, Page 4621-4632, Year 2014
Publish dateApr 21, 2014 (structure data deposition date)
AuthorsHanessian, S. / Saavedra, O.M. / Vilchis-Reyes, M.A. / Maianti, J.P. / Kanazawa, H. / Dozzo, P. / Matias, R.D. / Serio, A. / Kondo, J.
External linksChem Sci / Search PubMed
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-4pdq:
Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neomycin analog
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-NMZ:
(2S)-4-amino-N-{(1R,2S,3R,4R,5S)-5-amino-3-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy

ChemComp-HOH:
WATER

Source
  • synthetic (others)
KeywordsRNA/ANTIBIOTIC / ribosome / aminoglycoside / RNA-ANTIBIOTIC complex

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