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-Structure paper
Title | A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT). |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 5459-5463, Year 2014 |
Publish date | Mar 15, 2014 (structure data deposition date) |
![]() | Lanier, M. / Ambrus, G. / Cole, D.C. / Davenport, R. / Ellery, J. / Fosbeary, R. / Jennings, A.J. / Kadotani, A. / Kamada, Y. / Kamran, R. ...Lanier, M. / Ambrus, G. / Cole, D.C. / Davenport, R. / Ellery, J. / Fosbeary, R. / Jennings, A.J. / Kadotani, A. / Kamada, Y. / Kamran, R. / Matsumoto, S. / Mizukami, A. / Okubo, S. / Okada, K. / Saikatendu, K. / Walsh, L. / Wu, H. / Hixon, M.S. |
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Methods | X-ray diffraction |
Resolution | 2.06 Å |
Structure data | ![]() PDB-4p58: |
Chemicals | ![]() ChemComp-2F6: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / SAM binding site / TRANSFERASE-TRANSFERASE INHIBITOR complex |