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-Structure paper
Title | Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity. |
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Journal, issue, pages | Antimicrob. Agents Chemother., Vol. 58, Page 7484-7491, Year 2014 |
Publish date | Feb 11, 2014 (structure data deposition date) |
![]() | Lamb, K.M. / Lombardo, M.N. / Alverson, J. / Priestley, N.D. / Wright, D.L. / Anderson, A.C. |
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Methods | X-ray diffraction |
Resolution | 1.76 - 2.7 Å |
Structure data | ![]() PDB-4or7: ![]() PDB-4osg: |
Chemicals | ![]() ChemComp-NAP: ![]() ChemComp-25U: ![]() ChemComp-HOH: ![]() ChemComp-06U: ![]() ChemComp-EOH: ![]() ChemComp-CAC: ![]() ChemComp-CL: ![]() ChemComp-PEG: ![]() ChemComp-CA: |
Source |
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![]() | Oxidoreductase/Oxidoreductase inhibitor / 5 / 6 / 7 / 8-tetrahydrofolate; 7 / 8-dihydrofolate / hydride shift / Oxidoreductase-Oxidoreductase inhibitor complex / Oxidoreductase |