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TitleOverexpression of Pseudomonas aeruginosa LpxC in the Presence of an Inhibitor in an acrB Deletion Escherichia coli strain for Structural Studies
Journal, issue, pagesProtein Express. Purif., Year 2014
Publish dateJan 22, 2014 (structure data deposition date)
AuthorsGao, N. / McLeod, S.M. / Hajec, H. / Lahiri, S.D. / Prince, D.B. / Thresher, J. / Whiteaker, J. / Ross, P. / Olivier, N.B. / Doig, P.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.06 Å
Structure data

PDB-4okg:
LpxC from P.aeruginosa with the inhibitor 6-(benzimidazol-1-yl)-5-[4-[2-[6-[(4-methylpiperazin-1-yl)methyl]-3-pyridyl]ethynyl]phenyl]pyridine-3-carbohydroxamic acid
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-2SZ:
6-(1H-benzimidazol-1-yl)-N-hydroxy-5-[4-({6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl}ethynyl)phenyl]pyridine-3-carboxamide

ChemComp-HOH:
WATER

Source
  • pseudomonas aeruginosa (bacteria)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / hydroxamate / beta-alpha-alpha-beta sandwich / deacetylase / intracellular; cytoplasm / HYDROLASE-HYDROLASE INHIBITOR complex

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