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Structure paper

TitleInhibition of plasma kallikrein by a highly specific active site blocking antibody.
Journal, issue, pagesJ. Biol. Chem., Vol. 289, Page 23596-23608, Year 2014
Publish dateJan 16, 2014 (structure data deposition date)
AuthorsKenniston, J.A. / Faucette, R.R. / Martik, D. / Comeau, S.R. / Lindberg, A.P. / Kopacz, K.J. / Conley, G.P. / Chen, J. / Viswanathan, M. / Kastrapeli, N. ...Kenniston, J.A. / Faucette, R.R. / Martik, D. / Comeau, S.R. / Lindberg, A.P. / Kopacz, K.J. / Conley, G.P. / Chen, J. / Viswanathan, M. / Kastrapeli, N. / Cosic, J. / Mason, S. / DiLeo, M. / Abendroth, J. / Kuzmic, P. / Ladner, R.C. / Edwards, T.E. / TenHoor, C. / Adelman, B.A. / Nixon, A.E. / Sexton, D.J.
External linksJ. Biol. Chem. / PubMed:24970892
MethodsX-ray diffraction
Resolution1.75 - 2.4 Å
Structure data

PDB-4ogx:
Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.4 Angstrom resolution
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4ogy:
Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.1 Angstrom resolution
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4pub:
Crystal structure of Fab DX-2930
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsHYDROLASE/ANTIBODY / FAB / ANTIBODY / KALLIKREIN / BLOOD / PLASMA / PLASMA KALLIKREIN- MEDIATED EDEMA / ACUTE HEREDITARY ANGIOEDEMA / HAE / HMWK / serpin C1-inhibitor / C1-INH / hereditary angioedema / HAW / bradykinin / Fletcher factor / Kininogenin / serine protease / edema / HYDROLASE-ANTIBODY complex / IMMUNE SYSTEM / PLASMA KALLIKREIN-MEDIATED EDEMA

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