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-Structure paper
Title | Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. |
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Journal, issue, pages | Nat. Chem. Biol., Vol. 10, Page 305-312, Year 2014 |
Publish date | Jan 16, 2014 (structure data deposition date) |
Authors | Ciceri, P. / Muller, S. / O'Mahony, A. / Fedorov, O. / Filippakopoulos, P. / Hunt, J.P. / Lasater, E.A. / Pallares, G. / Picaud, S. / Wells, C. ...Ciceri, P. / Muller, S. / O'Mahony, A. / Fedorov, O. / Filippakopoulos, P. / Hunt, J.P. / Lasater, E.A. / Pallares, G. / Picaud, S. / Wells, C. / Martin, S. / Wodicka, L.M. / Shah, N.P. / Treiber, D.K. / Knapp, S. |
External links | Nat. Chem. Biol. / PubMed:24584101 |
Methods | X-ray diffraction |
Resolution | 1.65 - 1.73 Å |
Structure data | PDB-4ogi: PDB-4ogj: |
Chemicals | ChemComp-EDO: ChemComp-R78: ChemComp-HOH: ChemComp-2TA: |
Source |
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Keywords | TRANSCRIPTION/INHIBITOR / bromodomain / bromodomain containing protein 4 / PLK1 kinase inhibitor / structural genomics / Structural Genomics Consortium / SGC / TRANSCRIPTION-INHIBITOR complex / JAK2 kinase inhibitor / FLT3 kinase inhibitor |