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-Structure paper
Title | Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. |
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Journal, issue, pages | Elife, Vol. 3, Page e01998-e01998, Year 2014 |
Publish date | Nov 14, 2013 (structure data deposition date) |
![]() | Stamos, J.L. / Chu, M.L. / Enos, M.D. / Shah, N. / Weis, W.I. |
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Methods | X-ray diffraction |
Resolution | 2.1 - 2.5 Å |
Structure data | ![]() PDB-4nm0: ![]() PDB-4nm3: ![]() PDB-4nm5: ![]() PDB-4nm7: ![]() PDB-4nu1: |
Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-MG: ![]() ChemComp-ADP: ![]() ChemComp-DTT: ![]() ChemComp-CL: ![]() ChemComp-HOH: ![]() ChemComp-AF3: ![]() ChemComp-NO3: |
Source |
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![]() | TRANSFERASE/PEPTIDE / Wnt / LRP6 / Auto-inhibited / GSK-3 / Axin / kinase / primed substrate / TRANSFERASE-PEPTIDE complex / phosphorylated N-terminal auto-inhibitory pS9 peptide / phosphorylated Wnt receptor LRP6 c-motif / phosphorylated Wnt receptor LRP6 e-motif / transition state |