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-Structure paper
Title | Correlation between chemotype-dependent binding conformations of HSP90 alpha / beta and isoform selectivity-Implications for the structure-based design of HSP90 alpha / beta selective inhibitors for treating neurodegenerative diseases. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 24, Page 204-208, Year 2014 |
Publish date | Nov 4, 2013 (structure data deposition date) |
![]() | Ernst, J.T. / Liu, M. / Zuccola, H. / Neubert, T. / Beaumont, K. / Turnbull, A. / Kallel, A. / Vought, B. / Stamos, D. |
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Methods | X-ray diffraction |
Resolution | 1.65 - 2.77 Å |
Structure data | ![]() PDB-4nh7: ![]() PDB-4nh8: ![]() PDB-4nh9: |
Chemicals | ![]() ChemComp-E0G: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-2LC: |
Source |
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![]() | CHAPERONE / a/b fold / a/b protein / a/b structure / endoplasmic reticulum |