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Structure paper

TitleStructure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling.
Journal, issue, pagesCancer Cell, Vol. 26, Page 402-413, Year 2014
Publish dateSep 10, 2013 (structure data deposition date)
AuthorsHaling, J.R. / Sudhamsu, J. / Yen, I. / Sideris, S. / Sandoval, W. / Phung, W. / Bravo, B.J. / Giannetti, A.M. / Peck, A. / Masselot, A. ...Haling, J.R. / Sudhamsu, J. / Yen, I. / Sideris, S. / Sandoval, W. / Phung, W. / Bravo, B.J. / Giannetti, A.M. / Peck, A. / Masselot, A. / Morales, T. / Smith, D. / Brandhuber, B.J. / Hymowitz, S.G. / Malek, S.
External linksCancer Cell / PubMed:25155755
MethodsX-ray diffraction
Resolution2.802 - 2.8483 Å
Structure data

PDB-4mne:
Crystal structure of the BRAF:MEK1 complex
Method: X-RAY DIFFRACTION / Resolution: 2.8483 Å

PDB-4mnf:
Crystal structure of BRAF-V600E bound to GDC0879
Method: X-RAY DIFFRACTION / Resolution: 2.802 Å

Chemicals

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-573:
7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-{[(2S)-2-hydroxypropyl]oxy}furo[3,2-c]pyridine-2-carboxamide

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-29L:
2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / RAF / MAPK / kinase domain / ATP-binding / ERK / RAS / PAK / TRANSFERASE-TRANSFERASE INHIBITOR complex / active conformation

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