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TitleA Unique and Conserved Neutralization Epitope in H5N1 Influenza Viruses Identified by an Antibody against the A/Goose/Guangdong/1/96 Hemagglutinin.
Journal, issue, pagesJ. Virol., Vol. 87, Page 12619-12635, Year 2013
Publish dateAug 29, 2013 (structure data deposition date)
AuthorsZhu, X. / Guo, Y.H. / Jiang, T. / Wang, Y.D. / Chan, K.H. / Li, X.F. / Yu, W. / McBride, R. / Paulson, J.C. / Yuen, K.Y. ...Zhu, X. / Guo, Y.H. / Jiang, T. / Wang, Y.D. / Chan, K.H. / Li, X.F. / Yu, W. / McBride, R. / Paulson, J.C. / Yuen, K.Y. / Qin, C.F. / Che, X.Y. / Wilson, I.A.
External linksJ. Virol. / PubMed:24049169
MethodsX-ray diffraction
Resolution2.595 - 6.98 Å
Structure data

PDB-4mhh:
Crystal structure of Fab H5M9 in complex with influenza virus hemagglutinin from A/Viet Nam/1203/2004 (H5N1)
Method: X-RAY DIFFRACTION / Resolution: 3.564 Å

PDB-4mhi:
Crystal structure of a H5N1 influenza virus hemagglutinin from A/goose/Guangdong/1/96
Method: X-RAY DIFFRACTION / Resolution: 2.595 Å

PDB-4mhj:
Crystal structure of Fab H5M9 in complex with influenza virus hemagglutinin from A/goose/Guangdong/1/96 (H5N1)
Method: X-RAY DIFFRACTION / Resolution: 6.98 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • influenza a virus
  • mus musculus (house mouse)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / H5N1 influenza virus / broadly neutralizing murine antibody / escape mutant / passive immunotherapy / VIRAL PROTEIN-IMMUNE SYSTEM complex / VIRAL PROTEIN / epitope / glycoprotein / progenitor / broadly neutralizing antibody

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