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Structure paper

TitleStructures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue.
Journal, issue, pagesActa Crystallogr. ,Sect. D, Vol. 69, Page 2146-2156, Year 2013
Publish dateMay 22, 2013 (structure data deposition date)
AuthorsWallentine, B.D. / Wang, Y. / Tretyachenko-Ladokhina, V. / Tan, M. / Senear, D.F. / Luecke, H.
External linksActa Crystallogr. ,Sect. D / PubMed:24100332
MethodsX-ray diffraction
Resolution1.5 - 2.5 Å
Structure data

PDB-4kvp:
Human p53 Core Domain Mutant V157F
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-4lo9:
Human p53 Core Domain Mutant N235K
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-4loe:
Human p53 Core Domain Mutant N239Y
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-4lof:
Human p53 Core Domain Mutant V157F/N235K/N239Y
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsAPOPTOSIS / Tumor Suppressor Protein p53 / Cancer Mutation / Tumor / Protein Stability / Mutant Proteins / Beta Sandwich / Tumor Suppressor / DNA Binding / Nuclear

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