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Structure paper

TitleCrystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.
Journal, issue, pagesFebs Lett., Vol. 588, Page 1743-1748, Year 2014
Publish dateJun 21, 2013 (structure data deposition date)
AuthorsHilbert, B.J. / Grossmann, S.R. / Schiffer, C.A. / Royer, W.E.
External linksFebs Lett. / PubMed:24657618
MethodsX-ray diffraction
Resolution2.38 - 2.86 Å
Structure data

PDB-4lce:
CtBP1 in complex with substrate MTOB
Method: X-RAY DIFFRACTION / Resolution: 2.38 Å

PDB-4lcj:
CtBP2 in complex with substrate MTOB
Method: X-RAY DIFFRACTION / Resolution: 2.86 Å

Chemicals

ChemComp-NAD:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM

ChemComp-KMT:
4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE/OXIDOREDUCTASE SUBSTRATE / Rossmann Fold / Transcriptional Co-repressor / D-isomer 2-hydroxyacid dehydrogenase / OXIDOREDUCTASE-OXIDOREDUCTASE SUBSTRATE complex / Transcriptional Corepressor

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