タイトル | Sub-angstrom-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate. |
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ジャーナル・号・ページ | Nat Chem, Vol. 5, Page 762-767, Year 2013 |
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掲載日 | 2013年5月28日 (構造データの登録日) |
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著者 | Ludtke, S. / Neumann, P. / Erixon, K.M. / Leeper, F. / Kluger, R. / Ficner, R. / Tittmann, K. |
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リンク | Nat Chem / PubMed:23965678 |
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手法 | X線回折 |
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解像度 | 0.97 - 1.26 Å |
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構造データ | PDB-4kxu: Human transketolase in covalent complex with donor ketose D-fructose-6-phosphate 手法: X-RAY DIFFRACTION / 解像度: 0.98 Å PDB-4kxv: Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 1 手法: X-RAY DIFFRACTION / 解像度: 0.97 Å PDB-4kxw: Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 2 手法: X-RAY DIFFRACTION / 解像度: 0.97 Å PDB-4kxx: Human transketolase in covalent complex with donor ketose D-sedoheptulose-7-phosphate 手法: X-RAY DIFFRACTION / 解像度: 1.03 Å PDB-4kxy: Human transketolase in complex with ThDP analogue (R)-2-(1,2-dihydroxyethyl)-3-deaza-ThDP 手法: X-RAY DIFFRACTION / 解像度: 1.26 Å |
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化合物 | ChemComp-1Y7: (2R,3R,4S,5R,6S)-2,3,4,5,6,7-hexahydroxyheptyl dihydrogen phosphate
ChemComp-1U0: 2-{4-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-[(1R)-1,2-dihydroxyethyl]-3-methylthiophen-2-yl}ethyl trihydrogen diphosphate
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由来 | ![](img/tx_human.gif) homo sapiens (ヒト)
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キーワード | TRANSFERASE (転移酵素) / thiamin diphosphate (チアミンピロリン酸) / enzyme catalysis (酵素反応) / pentose phosphate pathway (ペントースリン酸経路) |
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