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Structure paper

TitleStructural basis for 2'-phosphate incorporation into glycogen by glycogen synthase.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page 20976-20981, Year 2013
Publish dateMay 14, 2013 (structure data deposition date)
AuthorsChikwana, V.M. / Khanna, M. / Baskaran, S. / Tagliabracci, V.S. / Contreras, C.J. / Depaoli-Roach, A. / Roach, P.J. / Hurley, T.D.
External linksProc. Natl. Acad. Sci. USA / PubMed:24324135
MethodsX-ray diffraction
Resolution2.66 - 2.95 Å
Structure data

PDB-4kq1:
Crystal structure of yeast glycogen synthase in complex with uridine-5'-monophosphate
Method: X-RAY DIFFRACTION / Resolution: 2.66 Å

PDB-4kq2:
Glucose1,2cyclic phosphate bound activated state of Yeast Glycogen Synthase
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

PDB-4kqm:
Crystal structure of yeast glycogen synthase E169Q mutant in complex with glucose and UDP
Method: X-RAY DIFFRACTION / Resolution: 2.77 Å

Chemicals

ChemComp-U5P:
URIDINE-5'-MONOPHOSPHATE / Uridine monophosphate

ChemComp-G6P:
6-O-phosphono-alpha-D-glucopyranose

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER / Diethylene glycol

ChemComp-BA:
Unknown entry

ChemComp-1S3:
(2R,3aR,5R,6S,7S,7aR)-5-(hydroxymethyl)tetrahydro-3aH-[1,3,2]dioxaphospholo[4,5-b]pyran-2,6,7-triol 2-oxide

ChemComp-UDP:
URIDINE-5'-DIPHOSPHATE / UDP*YM / Uridine diphosphate

ChemComp-GLC:
alpha-D-glucopyranose / Glucose

ChemComp-BGC:
beta-D-glucopyranose / Glucose

Source
  • saccharomyces cerevisiae fosterso (yeast)
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsTRANSFERASE / Glycosyltransferase / GT-B / Rossmann Fold / glucosylation / Glucosyltransferase

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