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-Structure paper
Title | Discovery of RG7388, a Potent and Selective p53-MDM2 Inhibitor in Clinical Development. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 5979-5983, Year 2013 |
Publish date | Mar 21, 2013 (structure data deposition date) |
Authors | Ding, Q. / Zhang, Z. / Liu, J.J. / Jiang, N. / Zhang, J. / Ross, T.M. / Chu, X.J. / Bartkovitz, D. / Podlaski, F. / Janson, C. ...Ding, Q. / Zhang, Z. / Liu, J.J. / Jiang, N. / Zhang, J. / Ross, T.M. / Chu, X.J. / Bartkovitz, D. / Podlaski, F. / Janson, C. / Tovar, C. / Filipovic, Z.M. / Higgins, B. / Glenn, K. / Packman, K. / Vassilev, L.T. / Graves, B. |
External links | J. Med. Chem. / PubMed:23808545 |
Methods | X-ray diffraction |
Resolution | 1.9 - 2.5 Å |
Structure data | PDB-4jrg: PDB-4jsc: |
Chemicals | ChemComp-I09: ChemComp-HOH: ChemComp-1OY: |
Source |
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Keywords | LIGASE/LIGASE INHIBITOR / protein-inhibitor complex / pyrrolidine / E3 ubiquitin ligase / P53 / nucleus / LIGASE-LIGASE INHIBITOR complex / ligase-antagonist complex |