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Title | Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations. |
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Journal, issue, pages | Antimicrob. Agents Chemother., Vol. 57, Page 6085-6096, Year 2013 |
Publish date | Mar 12, 2013 (structure data deposition date) |
![]() | Kurz, S.G. / Wolff, K.A. / Hazra, S. / Bethel, C.R. / Hujer, A.M. / Smith, K.M. / Xu, Y. / Tremblay, L.W. / Blanchard, J.S. / Nguyen, L. / Bonomo, R.A. |
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Methods | X-ray diffraction |
Resolution | 2.1 Å |
Structure data | ![]() PDB-4jlf: |
Chemicals | ![]() ChemComp-PO4: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / beta-lactams inactivation / tuberculosis / Drug Design / Multi drug resistance |