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Structure paper

TitleDeconstruction of a nutlin: dissecting the binding determinants of a potent protein-protein interaction inhibitor.
Journal, issue, pagesACS Med Chem Lett, Vol. 4, Page 660-665, Year 2013
Publish dateFeb 12, 2013 (structure data deposition date)
AuthorsFry, D.C. / Wartchow, C. / Graves, B. / Janson, C. / Lukacs, C. / Kammlott, U. / Belunis, C. / Palme, S. / Klein, C. / Vu, B.
External linksACS Med Chem Lett / PubMed:24900726
MethodsX-ray diffraction
Resolution1.2 - 1.63 Å
Structure data

PDB-4j74:
The 1.2A crystal structure of humanized Xenopus MDM2 with RO0503918 - a nutlin fragment
Method: X-RAY DIFFRACTION / Resolution: 1.2 Å

PDB-4j7d:
The 1.25A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5045331
Method: X-RAY DIFFRACTION / Resolution: 1.25 Å

PDB-4j7e:
The 1.63A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5524529
Method: X-RAY DIFFRACTION / Resolution: 1.63 Å

Chemicals

ChemComp-I18:
(4S,5R)-4,5-bis(4-chlorophenyl)-2-methyl-4,5-dihydro-1H-imidazole

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-I31:
(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole

ChemComp-I29:
[(4S,5R)-4,5-bis(4-chlorophenyl)-2,4,5-trimethyl-4,5-dihydro-1H-imidazol-1-yl]{4-[3-(methylsulfonyl)propyl]piperazin-1-yl}methanone

Source
  • xenopus laevis (African clawed frog)
KeywordsLIGASE/ANTAGONIST / MDM2 / IMIDAZOLINE / LIGASE-ANTAGONIST COMPLEX / E3 UBIQUITIN LIGASE / P53 / NUCLEUS / PROTEIN-PROTEIN INTERACTION

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