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Structure paper

TitleLpxI structures reveal how a lipid A precursor is synthesized.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 19, Page 1132-1138, Year 2012
Publish dateAug 6, 2012 (structure data deposition date)
AuthorsMetzger, L.E. / Lee, J.K. / Finer-Moore, J.S. / Raetz, C.R. / Stroud, R.M.
External linksNat. Struct. Mol. Biol. / PubMed:23042606
MethodsX-ray diffraction
Resolution2.52 - 2.897 Å
Structure data

PDB-4ggm:
Structure of LpxI
Method: X-RAY DIFFRACTION / Resolution: 2.897 Å

PDB-4j6e:
Structure of LPXI D225A Mutant
Method: X-RAY DIFFRACTION / Resolution: 2.52 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-LP5:
(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE

ChemComp-HOH:
WATER

ChemComp-UDG:
(2R,3R,4R,5S,6R)-2-{[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)-3-{[(3R)-3-hydroxytetradecanoyl]amino}tetrahydro-2H-pyran-4-yl (3R)-3-hydroxytetradecanoate

Source
  • caulobacter crescentus (bacteria)
KeywordsHYDROLASE / Structural Genomics / PSI-Biology / Protein Structure Initiative / Center for Structures of Membrane Proteins / CSMP / lipid binding

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