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-Structure paper
Title | Fragment-based ligand design of novel potent inhibitors of tankyrases. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 4497-4508, Year 2013 |
Publish date | Jan 18, 2013 (structure data deposition date) |
Authors | Larsson, E.A. / Jansson, A.E. / Ng, F.M. / Then, S.W. / Panicker, R. / Liu, B. / Sangthongpitag, K. / Pendharkar, V. / Tai, S.J. / Hill, J. ...Larsson, E.A. / Jansson, A.E. / Ng, F.M. / Then, S.W. / Panicker, R. / Liu, B. / Sangthongpitag, K. / Pendharkar, V. / Tai, S.J. / Hill, J. / Dan, C. / Ho, S.Y. / Cheong, W.W. / Poulsen, A. / Blanchard, S. / Lin, G.R. / Alam, J. / Keller, T.H. / Nordlund, P. |
External links | J. Med. Chem. / PubMed:23672613 |
Methods | X-ray diffraction |
Resolution | 1.9 - 2.38 Å |
Structure data | PDB-3w51: PDB-4iue: PDB-4j1z: PDB-4j21: PDB-4j22: PDB-4j3l: PDB-4j3m: |
Chemicals | ChemComp-AJ2: ChemComp-ZN: ChemComp-SO4: ChemComp-HOH: ChemComp-AJ4: ChemComp-495: ChemComp-AJ6: ChemComp-AJ7: ChemComp-AJ5: ChemComp-AJ8: ChemComp-GOL: |
Source |
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Keywords | TRANSFERASE / Ribosylation / ribosylations / CATALYTIC FRAGMENT / PARP / ADP-RIBOSYLATION / ANK REPEAT / GLYCOSYLTRANSFERASE / MEMBRANE / MRNA TRANSPORT / NAD / TELOMERE / TRANSLOCATION / WNT-SIGNALLING |