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Structure paper

TitleLinear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10.
Journal, issue, pagesHum. Mol. Genet., Vol. 22, Page 4215-4223, Year 2013
Publish dateJan 17, 2013 (structure data deposition date)
AuthorsKlein, F.A. / Zeder-Lutz, G. / Cousido-Siah, A. / Mitschler, A. / Katz, A. / Eberling, P. / Mandel, J.L. / Podjarny, A. / Trottier, Y.
External linksHum. Mol. Genet. / PubMed:23777629
MethodsX-ray diffraction
Resolution1.497 - 2.445 Å
Structure data

PDB-4isv:
Crystal structure of the Fab FRAGMENT OF 1C2, A MONOCLONAL ANTIBODY SPECIFIC FOR POLY-GLUTAMINE
Method: X-RAY DIFFRACTION / Resolution: 1.497 Å

PDB-4jj5:
CRYSTAL STRUCTURE OF THE Fab FRAGMENT OF 1C2, A MONOCLONAL ANTIBODY SPECIFIC for POLY-GLUTAMINE
Method: X-RAY DIFFRACTION / Resolution: 2.445 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / 1C2 / Fab / Vlx / Neurodegeneration / Polyglutamine Disease / Amyloid Disease / Immunoglobulin fold / Polyglutamine

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