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TitleA highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor.
Journal, issue, pagesJ. Biol. Chem., Vol. 288, Page 28068-28077, Year 2013
Publish dateDec 8, 2012 (structure data deposition date)
AuthorsAnastassiadis, T. / Duong-Ly, K.C. / Deacon, S.W. / Lafontant, A. / Ma, H. / Devarajan, K. / Dunbrack, R.L. / Wu, J. / Peterson, J.R.
External linksJ. Biol. Chem. / PubMed:23935097
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-4ibm:
Crystal structure of insulin receptor kinase domain in complex with an inhibitor Irfin-1
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-IR1:
5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3H-pyrazolo[3,4-c]pyridazin-3-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / irk / kinase / ATP binding / Phosphorylation / Membrane / TRANSFERASE-TRANSFERASE INHIBITOR complex

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