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Structure paper

TitleStructural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel.
Journal, issue, pagesNat Commun, Vol. 4, Page 1697-1697, Year 2013
Publish dateOct 5, 2012 (structure data deposition date)
AuthorsSauguet, L. / Howard, R.J. / Malherbe, L. / Lee, U.S. / Corringer, P.J. / Harris, R.A. / Delarue, M.
External linksNat Commun / PubMed:23591864
MethodsX-ray diffraction
Resolution2.65 - 3.1 Å
Structure data

PDB-4hfb:
The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo)
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-4hfc:
The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to 2-bromo-ethanol
Method: X-RAY DIFFRACTION / Resolution: 3.05 Å

PDB-4hfd:
The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to bromoform
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-4hfe:
The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to ethanol
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-4hfh:
The GLIC pentameric Ligand-Gated Ion Channel (wild-type) complexed to bromoform
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-PLC:
DIUNDECYL PHOSPHATIDYL CHOLINE / phospholipid*YM

ChemComp-HOH:
WATER

ChemComp-LMT:
DODECYL-BETA-D-MALTOSIDE / detergent*YM

ChemComp-BRJ:
2-BROMOETHANOL

ChemComp-MBR:
TRIBROMOMETHANE

ChemComp-EOH:
ETHANOL


ChemComp, No image

ChemComp-UNL:
Unknown ligand

Source
  • gloeobacter violaceus (bacteria)
KeywordsMEMBRANE PROTEIN / TRANSPORT PROTEIN / pentameric transmembrane channel / Ion-channel / ion channel

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