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Structure paper

TitleCrystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sites
Journal, issue, pagesChemmedchem, Vol. 8, Page 733-739, Year 2013
Publish dateAug 22, 2012 (structure data deposition date)
AuthorsKondo, J. / Koganei, M. / Maianti, J.P. / Ly, V.L. / Hanessian, S.
External linksChemmedchem / PubMed:23436717
MethodsX-ray diffraction
Resolution2.6 - 3 Å
Structure data

PDB-4gpw:
Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-hydroxysisomicin (P21212 form)
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-4gpx:
Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-hydroxysisomicin (P212121 form)
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-4gpy:
Crystal structure of the bacterial ribosomal decoding site in complex with 6'-hydroxysisomicin
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-6HS:
(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(hydroxymethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside

ChemComp-HOH:
WATER

KeywordsRNA/ANTIBIOTIC / ribosome / aminoglycoside / RNA-ANTIBIOTIC complex / antiprotozoal activity / antibacterial activity

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